CXCL12 guides optic pathway development
23 January 2024
A new study demonstrates that CXCL12 promotes the crossing of retinal ganglion cell axons.
A new paper published in the journal ¶Ù±ð±¹±ð±ô´Ç±è³¾±ð²Ô³ÙÌýdemonstrates that CXCL12 promotes the crossing of retinal ganglion cell axons.Ìý
A collaboration between UCL Institute of Ophthalmology'sÌýChristiana Ruhrberg and Laura Denti with researchers at the University of Aberdeen and Jena University Hospital, the study demonstrates that CXCL12 is expressed in the ventral diencephalon meninges, which neighbours the optic chiasmÌýwhere the axons extending from retinal ganglion cells are sorted into the two brain hemispheres to enable stereovision. This research identifies CXCL12 as a key factor in promoting axon growth across the optic chiasm to form theÌýcontralateral axon projections.
Links
Image
- Cover page of journal Development
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