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The EURO Ewing Consortium supports clinical trials for Ewing sarcoma.
rEECur
rEECur - International Randomised Controlled Trial of Chemotherapy for the Treatment of Recurrent and Primary Refractory Ewing Sarcoma
Publications
ASCO (2019) Results of the first interim assessment of rEECur, an international randomized controlled trial of chemotherapy for the treatment of recurrent and primary refractory Ewing sarcoma -
ASCO (2020)听Results of the second interim assessment of rEECur, an international randomized controlled trial of chemotherapy for the treatment of recurrent and primary refractory Ewing sarcoma (RR-ES) -
ASCO (2020)听Correlation of response with progression-free (PFS) and overall (OS) survival in relapsed/refractory Ewing sarcoma (RR-ES): Results from the rEECur trial. -
ASCO (2022)听Phase III assessment of topotecan and cyclophosphamide and high-dose ifosfamide in rEECur: An international randomized controlled trial of chemotherapy for the treatment of recurrent and primary refractory Ewing sarcoma (RR-ES) -
INTER-EWING-1
INTER-EWING-1 - CI Bernadette Brennan, University of Manchester, UK
iEuroEwing
iEuroEwing - CI Uta Dirksen, University Hospital Essen, Germany
Closed trials
Euro Ewing 2012
Euro Ewing 2012 - International Randomised Controlled Trial for the Treatment of Newly Diagnosed Ewing's Sarcoma Family of Tumours
This trial is now closed to recruitment.
Trial results
The trial found that the USA treatment (VDC-IE) received by patients was more effective and less听toxic, for all stages of newly diagnosed ES, than the European standard treatment (VIDE).
October 2022 -听Euro Ewing 2012 clinical trial results are published in the Lancet Journal
The results of the practice-changing clinical trial for patients with newly-diagnosed听Ewing sarcoma have been . Free access to the full article听will be available for a limited time, and for patients and the public, a , reviewed and edited by the EEC patient advocates can be 听as well as a , translated by one of the EEC patient advocates. The EEC would like to thank all the patients and researchers for their contribution to this important trial.
Publications
Comparison of two chemotherapy regimens in patients with newly diagnosed Ewing sarcoma (EE2012): an open-label, randomised, phase 3 trial - 听补苍诲
ASCO (2020)听Comparison of two chemotherapy regimens in Ewing sarcoma (ES): Overall and subgroup results of the Euro Ewing 2012 randomized trial (EE2012) -
Trials (2020)听International randomised controlled trial for the treatment of newly diagnosed EWING sarcoma family of tumours 鈥� EURO EWING 2012 Protocol -
Results for Euro Ewing 2012 and rEECur were posted in accordance with deliverables D1.6 and D2.6 in September 2018.
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