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UCL Division of Biosciences

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Circuits and Systems Neuroscience

Research in the Circuits and Systems laboratories in the department focuses on understanding the fundamental mechanisms of circuit and system function and how it contributes to emerging behaviours in health and disease. Laboratories use a combination of cutting-edge optical, genetic, pharmacological and electrophysiological techniques to measure and manipulate brain activity from a variety of cell-types to dissect and interrogate the circuit function.

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Common methodological approaches are used in the department to investigate a number of different themes, including sensory systems, hippocampal function, metabolic and cardiovascular physiology, neuroplasticity and learning, and pain. These systems are investigated during development, in adulthood and in ageing, and in different model systems, including rodents and zebrafish, as well as in humans.

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These laboratories share common goals of understanding the structure and function of circuits in the brain, how they change and how they underpin behaviour.

Major Themes Include:

  • Cardiovascular and Metabolic Neurophysiology
  • Synaptic and Circuit Correlates of Behaviour
  • Sensory neuroscience
  • Developmental Biology
  • Neuroplasticity and Learning
  • Physiology of Pain

People involved in this research theme:

Recent Papers

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mouse brain centered on the amygdala, with hippocampus -projecting neurons in cyan and inhibitory neurons in orange

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fast_odour_dynamics_are_encoded_in_the_olfactory_system_and_guide_behaviour

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comparison_of_the_peak_and_area_of_activation_of_the_dhbo_response_to_an_innocuous_touch_and_noxious_lance_mechanical_stimulation_of_the_heel

Coordinated Emergence of Hippocampal Replay and Theta Sequences during Post-natal Development

Learn More

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David Attwell:ÌýUK DRI – The role of capillary pericytes in health, stroke and Alzheimer's disease

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David Attwell:ÌýPhysiology 2021: Annual Review Prize LectureÌý

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Francesca Cacucci: The post-natal development of the hippocampal networks for memory and space

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Lorenzo Fabrizi:ÌýInterview with the Medical Research Foundation

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Maria Fitzgerald: Ethical issues of neuroscientific studies on fetuses and newly born babies

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Marie Holt (Trapp Lab):ÌýMind affects matter – brainstem circuits linking stress, physiology, and behaviour

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Tara Keck: Neuroplasticity in Isolation and Loneliness

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Stephanie Koch: Touch, pain and itch

Listen

  • Can I think myself thin? David Attwell on the
  • At what point are babies able to sense touch? Stephanie Koch on the
  • How the brain weighs evidence and makes decisions: Andrew Macaskill on UCL's Brain Stories Podcast